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Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension
  1. George A Heckman, MD, FRCPC
  1. Geriatrics and Internal Medicine
 McMaster University
 Hamilton, Ontario, Canada

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    Although not mentioned by your commentator, Dr Psaty,1 concerns have been raised over the heart failure results in ALLHAT.2 Asymptomatic left ventricular (LV) systolic dysfunction is common in older patients, particularly in men and in patients with cardiovascular risk factors.3–4 ALLHAT participants were high risk patients, and many may have had asymptomatic LV dysfunction that could have been unmasked at the start of the …

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