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In response:
  1. Bruce M Psaty, MD, PhD
  1. University of Washington
 Seattle, Washington, USA

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    Heckman reiterates a number of published criticisms of ALLHAT. In the Cardiovascular Health Study,1 only 46 (1.3%) of 3579 older adults without clinical cardiovascular disease had an abnormal ejection fraction on echocardiogram. New HF events in older adults usually occur with preserved systolic function.2 ACE inhibitors have not been evaluated in the …

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