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A 10 mg nomogram was more effective than a 5 mg nomogram for warfarin induction in outpatient venous thromboembolism

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 QUESTION: In outpatients with acute venous thromboembolism (VTE), is warfarin induction with a 10 mg nomogram more effective than with a 5 mg nomogram?


Randomised (allocation concealed*), blinded (clinicians, patients, and outcome assessors),* controlled trial with 90 day follow up.


4 Canadian academic centres.


201 patients who were ≥18 years of age (mean age 55 y, 56% men) and had objectively confirmed acute VTE (deep venous thrombosis or pulmonary embolism). Exclusion criteria were a baseline international normalized ratio (INR) >1.4, platelet count <50 × 109 cells/ml, need for hospital admission, use of oral anticoagulant therapy in the previous 2 weeks, or high risk of major bleeding. 90 day follow up was complete.


Patients were allocated …

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  • Source of funding: no external funding.

  • For correspondence: Dr M J Kovacs, London Health Sciences Centre, London, Ontario, Canada. michael.kovacs{at}

  • Abstract and commentary also appear in ACP Journal Club.

  • * See glossary.