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QUESTION: In outpatients with acute venous thromboembolism (VTE), is warfarin induction with a 10 mg nomogram more effective than with a 5 mg nomogram?
Randomised (allocation concealed*), blinded (clinicians, patients, and outcome assessors),* controlled trial with 90 day follow up.
4 Canadian academic centres.
201 patients who were ≥18 years of age (mean age 55 y, 56% men) and had objectively confirmed acute VTE (deep venous thrombosis or pulmonary embolism). Exclusion criteria were a baseline international normalized ratio (INR) >1.4, platelet count <50 × 109 cells/ml, need for hospital admission, use of oral anticoagulant therapy in the previous 2 weeks, or high risk of major bleeding. 90 day follow up was complete.
Patients were allocated …