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QUESTION: In patients with above optimal blood pressure (BP), what is the relative effectiveness of 2 behavioural interventions (established lifestyle recommendations [ELR] and ELR plus the Dietary Approaches to Stop Hypertension [DASH] diet) compared with advice only?
Design
Randomised (allocation concealed*), blinded (data collectors),* controlled trial with 6 months of follow up (PREMIER Clinical Trial).
Setting
4 clinical centres in Baltimore, Maryland; Baton Rouge, Louisiana; Durham, North Carolina; and Portland, Oregon, USA.
Patients
810 generally healthy adults who were ≥25 years of age (mean age 50 y, 62% women), had above optimal BP (mean systolic BP 120–159 mm Hg and diastolic BP 80–95 mm Hg during 3 screening visits), were not taking antihypertensive medication, and had a body mass index of 18.5–45.0. Exclusion criteria were regular use of drugs …
Footnotes
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Source of funding: National Institutes of Health.
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For correspondence: Dr L J Appel, Johns Hopkins Medical Institutions, Baltimore, MD, USA. lappel{at}jhmi.edu
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A modified version of this abstract appears in Evidence-Based Nursing.