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Therapeutics
Lifestyle recommendations reduced blood pressure in patients with above optimal blood pressure

https://doi.org/10.1136/ebm.8.6.174

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    (2003) JAMA 289, 2083. Appel LJ, Champagne CM, Harsha DW, et al.. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial.. ;. :. –93.
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 QUESTION: In patients with above optimal blood pressure (BP), what is the relative effectiveness of 2 behavioural interventions (established lifestyle recommendations [ELR] and ELR plus the Dietary Approaches to Stop Hypertension [DASH] diet) compared with advice only?

    Design

    Randomised (allocation concealed*), blinded (data collectors),* controlled trial with 6 months of follow up (PREMIER Clinical Trial).

    Setting

    4 clinical centres in Baltimore, Maryland; Baton Rouge, Louisiana; Durham, North Carolina; and Portland, Oregon, USA.

    Patients

    810 generally healthy adults who were ≥25 years of age (mean age 50 y, 62% women), had above optimal BP (mean systolic BP 120–159 mm Hg and diastolic BP 80–95 mm Hg during 3 screening visits), were not taking antihypertensive medication, and had a body mass index of 18.5–45.0. Exclusion criteria were regular use of drugs …

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    Footnotes

    • Source of funding: National Institutes of Health.

    • For correspondence: Dr L J Appel, Johns Hopkins Medical Institutions, Baltimore, MD, USA. lappel{at}jhmi.edu

    • A modified version of this abstract appears in Evidence-Based Nursing.

    • ↵* See glossary.