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Review: new generation antipsychotics do not induce fewer extrapyramidal side effects than low potency antipsychotics

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 QUESTION: In patients with schizophrenia, do new generation antipsychotics (NGAs) cause fewer extrapyramidal side effects (EPSs) than low potency antipsychotics (LPAs)?

Data sources

Studies were identified by searching the Cochrane Schizophrenia Group’s register of randomised trials (up to March 2002) and hand searching relevant journals and conference preceedings. Bibliographies of relevant articles were reviewed and manufacturers of new generation antipsychotics and authors of primary research articles were contacted for further studies and data verification.

Study selection

Studies were selected if they were randomised controlled trials (RCTs) that compared NGAs (eg, clozapine) with LPAs (eg, chlorpromazine) in patients with schizophrenia or other disorders with psychotic features.

Data extraction

2 reviewers independently extracted data on sample size, patient characteristics, details of the intervention, study duration and quality, and outcomes. The primary outcome was the number of patients who had ≥1 EPS. The major secondary outcome was the number of patients who achieved a clinically important …

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  • Source of funding: no external funding.

  • For correspondence: Dr S Leucht, Universität München, Klinikum rechts der Isar, München, Germany. stefan.leucht{at}