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Review: ophthalmic non-steroidal anti-inflammatory drugs reduce pain without delaying healing in acute corneal abrasions

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 QUESTION: In patients with acute corneal abrasions, do ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) reduce pain without a delay in healing?

Data sources

Studies were identified by searching Medline (1966 to April 2002), the Cochrane Database of Systematic Reviews, ACP Journal Club, DARE, and the Cochrane Controlled Trials Registry and by reviewing bibliographies of relevant articles.

Study selection

Studies were selected if they were randomised controlled trials (RCTs) that compared ophthalmic NSAIDs with placebo, oral analgesic, or standard therapy in patients with acute corneal abrasions.

Data extraction

Data were extracted on sample size, study setting and quality, details of the intervention, and outcomes. The main outcomes included pain intensity (visual analogue scale or Numeric Pain Intensity Scale score) and time to …

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  • Source of funding: no external funding.

  • For correspondence: Dr C S Weaver, Indiana University School of Medicine, Indianapolis, Indiana, USA. chsweave{at}