Article Text

Download PDFPDF
Review: depression, social isolation, and certain life events are associated with the development of coronary heart disease

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: Are certain psychosocial risk factors (stressors) associated with the development and progression of coronary heart disease (CHD)?

Data sources

Reviews were identified by searching Medline, EMBASE/Excerpta Medica, and PsycINFO using 47 search terms to describe study design, outcomes, and stressors. Reference lists of reviews and personal files of the investigators were also searched.

Study selection

Reviews were selected if they were published in English in peer reviewed journals after 1979 and included prospective studies with ≥100 patients, and if CHD outcomes included myocardial infarction, myocardial revascularisation, and CHD death.

Data extraction

2 investigators independently assessed the quality of the selected reviews using a validated 7 point score. For reviews with a score ≥4, data were extracted on years covered, reviewers’ backgrounds, …

View Full Text


  • Sources of funding: National Heart Foundation of Australia and Beyondblue: the National Depression Initiative.

  • For correspondence: Dr S J Bunker, National Heart Foundation, Melbourne, Victoria, Australia. steve.bunker{at}