Article Text

Download PDFPDF
Carvedilol was more effective than metoprolol tartrate for lowering mortality in chronic heart failure

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q In patients with chronic heart failure (CHF), what is the comparative effectiveness of carvedilol and metoprolol tartrate on morbidity and mortality?

Clinical impact ratings Internal medicine ★★★★★★☆ IM/Ambulatory ★★★★★★☆ Cardiology ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial (Carvedilol Or Metoprolol European Trial [COMET]).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}.*

Embedded ImageFollow up period:

mean 58 months.

Embedded ImageSetting:

341 centres in 15 European countries.

Embedded ImagePatients:

3029 patients (mean age 62 y, 80% men, 99% white) with symptomatic CHF and left ventricular ejection fraction ⩽0.35. Patients had ⩾1 cardiovascular admission in the previous 2 years and were on stable heart failure treatment with angiotensin converting enzyme inhibitors for ⩾4 weeks and treatment …

View Full Text


  • * See glossary.

  • Information provided by author.

  • Abstract and commentary also appear in ACP Journal Club.

  • For correspondence: Professor P A Poole-Wilson, National Heart and Lung Institute, London, UK.

  • Sources of funding: F Hoffman La Roche and GlaxoSmithKline.

Linked Articles