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Q In patients with chronic heart failure (CHF), what is the comparative effectiveness of carvedilol and metoprolol tartrate on morbidity and mortality?
Clinical impact ratings Internal medicine ★★★★★★☆ IM/Ambulatory ★★★★★★☆ Cardiology ★★★★★★☆
METHODS
Design:
randomised controlled trial (Carvedilol Or Metoprolol European Trial [COMET]).
Allocation:
{concealed*}†.
Blinding:
blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}†.*
Follow up period:
mean 58 months.
Setting:
341 centres in 15 European countries.
Patients:
3029 patients (mean age 62 y, 80% men, 99% white) with symptomatic CHF and left ventricular ejection fraction ⩽0.35. Patients had ⩾1 cardiovascular admission in the previous 2 years and were on stable heart failure treatment with angiotensin converting enzyme inhibitors for ⩾4 weeks and treatment …
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