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Therapeutics
Oral topiramate was effective as an adjunct to standardised medication compliance management in alcohol dependence

https://doi.org/10.1136/ebm.9.1.24

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    Johnson BA, Ait-Daoud N, Bowden CL, et al. Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet 2003;361:1677–85.
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 Q In adults with alcohol dependence, is oral topiramate effective for reducing drinking, promoting abstinence, and decreasing craving as an adjunct to standardised medication compliance management?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial.

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    blinded {participants, healthcare providers, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}†.*

    Embedded ImageFollow up period:

    12 weeks.

    Embedded ImageSetting:

    San Antonio, Texas, USA.

    Embedded ImagePatients:

    158 participants between 21 and 65 years of age who met DSM-IV criteria for alcohol dependence; scored ⩾8 on the alcohol use disorders identification test; reported drinking a mean of ⩾35 standard drinks/week for men and ⩾21 standard drinks/week for women during the 90 days before enrolment; and had a negative urine toxicological screen for narcotics, amphetamines, or sedative hypnotics. Exclusion criteria included a current axis 1 psychiatric diagnosis (other than …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Professor B A Johnson, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. bjohnsonuthscsa

    • Sources of funding: Ortho-McNeil Pharmaceutical Inc, and University of Texas Health Science Center.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2004; 9 32-32 Published Online First: 18 Feb 2004. doi: 10.1136/ebm.9.1.32