Article Text

Download PDFPDF
Oral topiramate was effective as an adjunct to standardised medication compliance management in alcohol dependence

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


 
 Q In adults with alcohol dependence, is oral topiramate effective for reducing drinking, promoting abstinence, and decreasing craving as an adjunct to standardised medication compliance management?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆

METHODS

Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:

{concealed*}.

Embedded ImageBlinding:

blinded {participants, healthcare providers, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}.*

Embedded ImageFollow up period:

12 weeks.

Embedded ImageSetting:

San Antonio, Texas, USA.

Embedded ImagePatients:

158 participants between 21 and 65 years of age who met DSM-IV criteria for alcohol dependence; scored ⩾8 on the alcohol use disorders identification test; reported drinking a mean of ⩾35 standard drinks/week for men and ⩾21 standard drinks/week for women during the 90 days before enrolment; and had a negative urine toxicological screen for narcotics, amphetamines, or sedative hypnotics. Exclusion criteria included a current axis 1 psychiatric diagnosis (other than …

View Full Text

Footnotes

  • * See glossary.

  • Information provided by author.

  • For correspondence: Professor B A Johnson, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. bjohnsonuthscsa

  • Sources of funding: Ortho-McNeil Pharmaceutical Inc, and University of Texas Health Science Center.

Linked Articles

  • Glossary
    BMJ Publishing Group Ltd