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Oral topiramate was effective as an adjunct to standardised medication compliance management in alcohol dependence

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 Q In adults with alcohol dependence, is oral topiramate effective for reducing drinking, promoting abstinence, and decreasing craving as an adjunct to standardised medication compliance management?

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Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {participants, healthcare providers, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}.*

Embedded ImageFollow up period:

12 weeks.

Embedded ImageSetting:

San Antonio, Texas, USA.

Embedded ImagePatients:

158 participants between 21 and 65 years of age who met DSM-IV criteria for alcohol dependence; scored ⩾8 on the alcohol use disorders identification test; reported drinking a mean of ⩾35 standard drinks/week for men and ⩾21 standard drinks/week for women during the 90 days before enrolment; and had a negative urine toxicological screen for narcotics, amphetamines, or sedative hypnotics. Exclusion criteria included a current axis 1 psychiatric diagnosis (other than …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Professor B A Johnson, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. bjohnsonuthscsa

  • Sources of funding: Ortho-McNeil Pharmaceutical Inc, and University of Texas Health Science Center.

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