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Q In adults with alcohol dependence, is oral topiramate effective for reducing drinking, promoting abstinence, and decreasing craving as an adjunct to standardised medication compliance management?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆
METHODS
Design:
randomised placebo controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded {participants, healthcare providers, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}†.*
Follow up period:
12 weeks.
Setting:
San Antonio, Texas, USA.
Patients:
158 participants between 21 and 65 years of age who met DSM-IV criteria for alcohol dependence; scored ⩾8 on the alcohol use disorders identification test; reported drinking a mean of ⩾35 standard drinks/week for men and ⩾21 standard drinks/week for women during the 90 days before enrolment; and had a negative urine toxicological screen for narcotics, amphetamines, or sedative hypnotics. Exclusion criteria included a current axis 1 psychiatric diagnosis (other than …
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