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Review: the only effect for surgery plus antiobiotics in vesicoureteric reflux is fewer febrile urinary tract infections

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 Q In children with vesicoureteric reflux (VUR), which treatments reduce urinary tract infection (UTI) and renal parenchymal injury?

Clinical impact ratings GP/FP/Primary care ★★★★★★★


Embedded ImageData sources:

Medline, EMBASE/Excerpta Medica (to February 2003), and the Cochrane Controlled Trials Register; reference lists; and contact with authors.

Embedded ImageStudy selection and assessment:

randomised (RCTs) or quasi-randomised controlled trials that evaluated surgery (open and closed techniques), antibiotic prophylaxis, non-invasive techniques (eg, management of voiding dysfunction), or any combination of interventions in patients of any age with VUR. 3 reviewers independently evaluated the quality of studies.

Embedded ImageOutcomes:

incidence of UTI and renal parenchymal injury.


8 RCTs of 947 children <15 years of age were included. Studies originated in the US, Europe, and New Zealand. Antibiotic prophylaxis …

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  • For correspondence: Associate Professor J Craig, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

  • Source of funding: Australian Kidney Foundation.