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Q In children with vesicoureteric reflux (VUR), which treatments reduce urinary tract infection (UTI) and renal parenchymal injury?
Clinical impact ratings GP/FP/Primary care ★★★★★★★
METHODS
Data sources:
Medline, EMBASE/Excerpta Medica (to February 2003), and the Cochrane Controlled Trials Register; reference lists; and contact with authors.
Study selection and assessment:
randomised (RCTs) or quasi-randomised controlled trials that evaluated surgery (open and closed techniques), antibiotic prophylaxis, non-invasive techniques (eg, management of voiding dysfunction), or any combination of interventions in patients of any age with VUR. 3 reviewers independently evaluated the quality of studies.
Outcomes:
incidence of UTI and renal parenchymal injury.
MAIN RESULTS
8 RCTs of 947 children <15 years of age were included. Studies originated in the US, Europe, and New Zealand. Antibiotic prophylaxis …
Footnotes
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For correspondence: Associate Professor J Craig, The Children's Hospital at Westmead, Sydney, New South Wales, Australia. joncpub.health.usyd.edu.au
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Source of funding: Australian Kidney Foundation.