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Therapeutics
Ximelagatran was non-inferior to warfarin in preventing stroke and systemic embolism in atrial fibrillation

https://doi.org/10.1136/ebm.9.2.43

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    Olsson SB. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial. Lancet 2003;362:1691–8.
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 Q In patients with atrial fibrillation (AF) at risk for ischaemic stroke, is ximelagatran non-inferior to warfarin in preventing stroke and systemic embolism?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★★ Internal medicine ★★★★★★★ Cardiology ★★★★★★☆ Haematology ★★★★★★★

    METHODS

    Embedded ImageDesign:

    randomised controlled trial (Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation [SPORTIF]).

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (outcome assessors).*

    Embedded ImageFollow up:

    mean 17.4 months.

    Embedded ImageSetting:

    259 hospitals, doctor’s offices, and clinics in 23 countries.

    Embedded ImagePatients:

    3410 patients ⩾18 years of age who had nonvalvular AF and ⩾1 additional risk factor for stroke: treatment for hypertension but blood pressure <180/100 mm Hg; age ⩾75 years; previous stroke, transient ischaemic attack (TIA), or systemic embolism; left ventricular dysfunction; or age …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Professor S B Olsson, University Hospital, Lund, Sweden. bertil.olssonkard.lu.se

    • Source of funding: AstraZeneca.

    Linked Articles

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2004; 9 64-64 Published Online First: 16 Apr 2004. doi: 10.1136/ebm.9.2.64