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Sertraline reduced the severity of patients’ depressive symptoms in major depressive disorder

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 Q In children and adolescents with major depressive disorder (MDD), is sertraline more effective than placebo for reducing the severity of patients’ depressive symptoms?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★★★★


Embedded ImageDesign:

2 randomised placebo controlled trials with preplanned pooling of results. Patients were stratified into children and adolescents before randomisation.

Embedded ImageAllocation:


Embedded ImageBlinding:

patients and clinicians.*

Embedded ImageFollow up period:

10 weeks of treatment.

Embedded ImageSetting:

53 hospital, general practice, and academic centres in the US, India, Canada, Costa Rica, and Mexico.

Embedded ImagePatients:

376 children and adolescents (age range 6–17 y, 51% girls) who met criteria for MDD according to the DSM-IV and Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children—Present and Lifetime Version, and had had the current episode of MDD for ⩾6 weeks. Patients were also required to have a …

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  • * See glossary.

  • For correspondence: Dr K D Wagner, University of Texas Medical Branch, Galveston, TX, USA.

  • Source of funding: Pfizer Inc.

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