Article Text
PDF
Statistics from Altmetric.com
Q In children and adolescents with major depressive disorder (MDD), is sertraline more effective than placebo for reducing the severity of patients’ depressive symptoms?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★★★★
METHODS
Design:
2 randomised placebo controlled trials with preplanned pooling of results. Patients were stratified into children and adolescents before randomisation.
Allocation:
unclear.*
Blinding:
patients and clinicians.*
Follow up period:
10 weeks of treatment.
Setting:
53 hospital, general practice, and academic centres in the US, India, Canada, Costa Rica, and Mexico.
Patients:
376 children and adolescents (age range 6–17 y, 51% girls) who met criteria for MDD according to the DSM-IV and Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children—Present and Lifetime Version, and had had the current episode of MDD for ⩾6 weeks. Patients were also required to have a …
Footnotes
-
For correspondence: Dr K D Wagner, University of Texas Medical Branch, Galveston, TX, USA. kwagnerutmb.edu
-
Source of funding: Pfizer Inc.
Linked Articles
- Glossary