Article Text

Download PDFPDF

Sertraline reduced the severity of patients’ depressive symptoms in major depressive disorder
Free

Statistics from Altmetric.com


 
 Q In children and adolescents with major depressive disorder (MDD), is sertraline more effective than placebo for reducing the severity of patients’ depressive symptoms?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★★★★

METHODS

Embedded ImageDesign:

2 randomised placebo controlled trials with preplanned pooling of results. Patients were stratified into children and adolescents before randomisation.

Embedded ImageAllocation:

unclear.*

Embedded ImageBlinding:

patients and clinicians.*

Embedded ImageFollow up period:

10 weeks of treatment.

Embedded ImageSetting:

53 hospital, general practice, and academic centres in the US, India, Canada, Costa Rica, and Mexico.

Embedded ImagePatients:

376 children and adolescents (age range 6–17 y, 51% girls) who met criteria for MDD according to the DSM-IV and Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children—Present and Lifetime Version, and had had the current episode of MDD for ⩾6 weeks. Patients were also required to have a …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Glossary
    BMJ Publishing Group Ltd