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Oestrogen plus progestogen did not reduce the risk of coronary heart disease in postmenopausal women

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 Q In postmenopausal women, how does oestrogen plus progestogen influence the risk of coronary heart disease (CHD)?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★☆☆ Cardiology ★★★★★☆☆


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee).

Embedded ImageFollow up period:

5.6 years (Women’s Health Initiative [WHI]).

Embedded ImageSetting:

{40 US clinical centres}*.

Embedded ImagePatients:

16 608 postmenopausal women who were 50–79 years of age (mean age 63 y), had an intact uterus, and resided in the same geographic area for ⩾3 years.

Embedded ImageInterventions:

patients were allocated to oral conjugated equine oestrogen, 0.625 mg/day, plus medroxyprogesterone acetate, 2.5 mg/day (n = 8506), or placebo (n = 8102).

Embedded ImageOutcomes:

CHD (ie, acute myocardial infarction [MI] requiring overnight hospital admission; death …

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