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The following articles are abstracted in the May/Jun 2004 issue of ACP Journal Club. The declarative title of each abstract as published in ACP Journal Club precedes the article citation.
THERAPEUTICS
▸ Review: Commonly used antihypertensive therapies and targeted blood pressure-lowering regimens reduce cardiovascular events
▸ Review: Spironolactone may be effective for hirsutism but data are lacking on its effectiveness for acne vulgaris in women
▸ Review: Plasma exchange or intravenous immunoglobulin reduces disability in the Guillain-Barré syndrome
▸ Review: Anti-tumor necrosis factor-α directed therapies are recommended for NSAID-refractory spondyloarthritis
▸ Review: Hospital-at-home care does not increase mortality or readmission rates in acute exacerbations of COPD
▸ Review: Vitamin E, vitamin C, and possibly coenzyme Q10 are ineffective for preventing or treating cardiovascular disease
▸ Cognitive behavioral therapy aided discontinuation of benzodiazepine in chronic insomnia
▸ Parathyroid hormone (1–84) plus alendronate was not better than monotherapy with either agent in postmenopausal osteoporosis
▸ Parathyroid hormone (1–34) alone was better than parathyroid hormone plus alendronate in men with osteoporosis
▸ Buprenorphine alone or in combination with naloxone reduced the use of and craving for opiates in opiate addiction
▸ Structured interruption of treatment hastened disease progression in multidrug-resistant HIV
▸ Fondaparinux was not inferior to unfractionated heparin for symptomatic pulmonary embolism
▸ An exercise and behavioral management program reduced functional dependence in Alzheimer disease
▸ Cannabinoids did not reduce muscle spasticity in stable multiple sclerosis
PROGNOSIS
▸ Patients with West Nile virus meningitis or encephalitis, but not acute flaccid paralysis, had favorable outcomes
AETIOLOGY
▸ A 2 fitness-related variables—exercise capacity and heart rate recovery—predicted mortality in asymptomatic women
CLINICAL PREDICTION GUIDE
▸ A clinical prediction rule containing 6 variables accurately predicted hypersensitivity pneumonitis