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Levalbuterol reduced admissions more than racemic albuterol in children with acute asthma

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 Q In children presenting to the emergency department (ED) with acute asthma, does levalbuterol reduce hospital admissions compared with racemic albuterol?

Clinical impact ratings Respirology ★★★★★☆☆ Paediatrics ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, clinicians, data collectors, outcome assessors, data analysts, and manuscript writers}.*

Embedded ImageFollow up period:

to discharge or hospital admission.

Embedded ImageSetting:

the paediatric ED of a university affiliated, tertiary care children’s hospital in Cleveland, Ohio, USA.

Embedded ImagePatients:

552 enrolments of 482 children who were 1–18 years of age (mean age 7 y, 67% boys), had physician diagnosed asthma, and presented to the ED with acute asthma. {Children re-presenting were re-randomised each time.} Exclusion criteria: first episode of wheezing; lack of current asthma treatment; pregnancy; known hypersensitivity to albuterol; cystic fibrosis; cyanotic or uncorrected congenital heart disease; chronic …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr C M Kercsmar, Case Western Reserve University, Cleveland, OH, USA.

  • Source of funding: Sepracor.

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