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- pulmonary disease (chronic obstructive)
- adrenergic beta-agonists
- bronchodilator agents
- cholinergic antagonists
Q What are the effects of common treatments for chronic obstructive pulmonary disease (COPD) on patient outcomes?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Respirology ★★★★★☆☆
Medline (1980 to 1 May 2002), Cochrane Database of Systematic Reviews, bibliographies of published articles, and experts.
Study selection and assessment:
English language randomised controlled trials with ⩾3 months of follow up in adults with COPD that assessed long acting (LA) β2 agonists (β2As); LA inhaled anticholinergics (tiotropium); combined short acting (SA) β2As and SA anticholinergics; inhaled corticosteroids; combined inhaled corticosteroids and LAβ2As; pulmonary rehabilitation (with ⩾6 wks follow up); long term nocturnal non-invasive mechanical ventilation; domiciliary O2 therapy; or disease management. Analysis …
↵* Information provided by author.
For correspondence: Dr D D Sin, James Hogg iCAPTURE Center for Pulmonary and Cardiovascular Research, Vancouver, British Columbia, Canada.
Sources of funding: Canadian Institutes of Health Research and Alberta Heritage Foundation for Medical Research.