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Review: evidence exists for 33 different treatment options for osteoarthritis of the knee

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 Q What is the evidence for therapeutic interventions used in knee osteoarthritis (OA)?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Rheumatology ★★★★★☆☆


Embedded ImageData sources:

Medline and BIDS EMBASE/Excerpta Medica (1999 to February 2002 for treatments previously investigated and 1966 to February 2002 for all others).

Embedded ImageStudy selection and assessment:

systematic reviews, meta analyses, randomised controlled trials (RCTs), non-randomised controlled trials, and observational studies in English or other European languages were included if they assessed a treatment for pain or function, or both, in knee OA. Knee OA had to be supported by clinical and/or radiological evidence. Studies combining knee OA treatment with other types of OA were excluded. Studies were assessed for quality.

Embedded ImageOutcomes:

pain, function, and toxicity.


103 intervention trials were identified for the overall analysis that involved 33 interventions including non-pharmacological, pharmacological, intra-articular, and surgical treatments for knee OA. Quality scores …

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  • For correspondence: Professor M Dougados, Hôpital Cochin, Paris, France.

  • Source of funding: Bristol Myers Squibb.