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Q What is the evidence for therapeutic interventions used in knee osteoarthritis (OA)?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Rheumatology ★★★★★☆☆
Medline and BIDS EMBASE/Excerpta Medica (1999 to February 2002 for treatments previously investigated and 1966 to February 2002 for all others).
Study selection and assessment:
systematic reviews, meta analyses, randomised controlled trials (RCTs), non-randomised controlled trials, and observational studies in English or other European languages were included if they assessed a treatment for pain or function, or both, in knee OA. Knee OA had to be supported by clinical and/or radiological evidence. Studies combining knee OA treatment with other types of OA were excluded. Studies were assessed for quality.
pain, function, and toxicity.
103 intervention trials were identified for the overall analysis that involved 33 interventions including non-pharmacological, pharmacological, intra-articular, and surgical treatments for knee OA. Quality scores …
For correspondence: Professor M Dougados, Hôpital Cochin, Paris, France.
Source of funding: Bristol Myers Squibb.