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Therapeutics
Topical nitric oxide relieved pain and symptoms in chronic extensor tendinosis at the elbow

https://doi.org/10.1136/ebm.9.3.87

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    Paoloni JA, Appleyard RC, Nelson J, et al. Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial. Am J Sports Med 2003;31:915–20.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In patients with chronic extensor tendinosis at the elbow (tennis elbow), does topical nitric oxide improve outcome?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    blinded (patients and outcome assessors).*

    Embedded ImageFollow up period:

    6 months.

    Embedded ImageSetting:

    Sydney, New South Wales, Australia.

    Embedded ImagePatients:

    86 patients (95 elbows) who were 30–74 years of age (median age 46 y, 51% women) and had extensor tendinosis for ⩾3 months. Exclusion criteria: pregnancy, previous surgery, dislocation of the affected wrist or elbow, distal neurological signs, or a local corticosteroid injection in the previous 3 months.

    Embedded ImageIntervention:

    43 patients were allocated to an active transdermal patch (1/4 of a 5 mg …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Professory G A C Murrell, University of New South Wales, Sydney, New South Wales, Australia. murrell.gori.org.au

    • Source of funding: in part, St George Hospital—South Eastern Sydney Area Health Services.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2004; 9 96-96 Published Online First: 28 May 2004. doi: 10.1136/ebm.9.3.96