Article Text

Download PDFPDF

Ximelagatran prevented secondary venous thromboembolism
Free

Statistics from Altmetric.com


 
 Q What is the long term efficacy and safety of ximelagatran after 6 months of standard anticoagulant therapy for secondary prevention of venous thromboembolism (VTE)?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Haematology ★★★★★★★

METHODS

Embedded ImageDesign:

randomised placebo controlled trial (Thrombin Inhibitor in Venous Thromboembolism [THRIVE III]).

Embedded ImageAllocation:

concealed.*

Embedded ImageBlinding:

blinded (clinicians, patients, {data collectors, outcome assessors, and data analysts}).*

Embedded ImageFollow up period:

18 months.

Embedded ImageSetting

142 centres in 18 countries.

Embedded ImagePatients

1233 patients who were ⩾18 years of age with symptomatic, objectively confirmed deep venous thrombosis (DVT) or pulmonary embolism (PE) and had received anticoagulant therapy for 6 months with no recurrent VTE event. Exclusion criteria: indication for continuous anticoagulant therapy, haemoglobin level <9.0 g/dl, platelet count <90 000/mm3, pregnancy, lactation, expected survival <18 months, renal impairment, clinically important liver disease, or persistent elevation of the aminotransferase level >3 times the upper limit of normal.

Embedded ImageIntervention:

twice daily ximelagatran, 24 mg (n = 612), or placebo (n = 611) for 18 months. All patients discontinued anticoagulant therapy but did not begin study treatment until …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.