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Q In patients with asthma, how do different allergen specific (AS) immunotherapies compare for reducing asthma symptoms, medication requirements, and improving bronchial hyper-reactivity (BHR)?
GP/FP/Primary care ★★★★★☆☆ IM/Internal medicine ★★★★★☆☆ Allergy ★★★★★★☆ Respirology ★★★★★☆☆ Immunology ★★★★★★☆
METHODS
Data sources:
Medline (1966 to December 2001), the Cochrane Airways Group trials register (up to June 2001), EMBASE/Excerpta Medica, CINAHL, Current Contents, abstracts of dissertations, and reference lists.
Study selection and assessment:
studies in any language were selected if they were randomised controlled trials (RCTs) comparing AS immunotherapy with placebo, antigenically inactive controls, untreated controls, or inhaled steroids; or comparing house dust extract with placebo. Studies were assessed for methodological quality using the Jadad scale.
Outcomes:
asthma symptoms, medication requirements, lung …
Footnotes
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For correspondence: Associate Professor M Abramson, Monash University, Prahran, Victoria, Australia. michael.abramsonmed.monash.edu.au
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Source of funding: Garfield Weston Foundation, UK.
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Abstract and commentary also appear in ACP Journal Club.