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Smokers and ex-smokers with chronic stable asthma did not respond to high dose oral corticosteroids

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 Q In patients with chronic stable asthma, is bronchodilator and symptomatic response to high dose oral corticosteroids affected by smoking status?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Respirology ★★★★★★☆


Embedded ImageDesign:

randomised, placebo controlled, crossover study.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, clinicians, data collectors, outcome assessors, and data analysts}.*

Embedded ImageFollow up period:

2 weeks.

Embedded ImageSetting:

hospital clinics in Glasgow, UK

Embedded ImagePatients:

59 patients who were 18–55 years of age (mean age 42 y, 72% men; based on 50 patients), had chronic asthma, forced expiratory volume in 1 second (FEV1) of 50–85% predicted, and ⩾15% reversibility of FEV1 after nebulised albuterol (2.5 mg). Exclusion criteria: asthma exacerbation, use of oral …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Professor N C Thomson, Western Infirmary, Glasgow, UK.

  • Source of funding: National Asthma Campaign.