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Therapeutics
Smokers and ex-smokers with chronic stable asthma did not respond to high dose oral corticosteroids

https://doi.org/10.1136/ebm.9.4.115

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    Chaudhuri R, Livingston E, McMahon AD, et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003;168:1308–11.
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 Q In patients with chronic stable asthma, is bronchodilator and symptomatic response to high dose oral corticosteroids affected by smoking status?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Respirology ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised, placebo controlled, crossover study.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded {patients, clinicians, data collectors, outcome assessors, and data analysts}†.*

    Embedded ImageFollow up period:

    2 weeks.

    Embedded ImageSetting:

    hospital clinics in Glasgow, UK

    Embedded ImagePatients:

    59 patients who were 18–55 years of age (mean age 42 y, 72% men; based on 50 patients), had chronic asthma, forced expiratory volume in 1 second (FEV1) of 50–85% predicted, and ⩾15% reversibility of FEV1 after nebulised albuterol (2.5 mg). Exclusion criteria: asthma exacerbation, use of oral …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Professor N C Thomson, Western Infirmary, Glasgow, UK. n.c.thomsonclinmed.gla.ac.uk

    • Source of funding: National Asthma Campaign.