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Q In household contacts (HHCs) (after index influenza [flu] patients received oseltamivir), is postexposure prophylaxis (PEP) more effective than oseltamivir treatment at the time of illness (expectant treatment) for preventing flu transmission?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Infectious diseases ★★★★★★☆
cluster (household level) randomised controlled trial.
Follow up period:
households in Europe and North America.
812 HHCs (age range 1–83 y, 55% girls/women) of index patients with a flu like illness during a community flu outbreak. Eligible households had 3–8 members, including ⩾1 index patient and ⩾2 eligible contacts ⩾1 year of age. Exclusion criteria included pregnancy, breastfeeding, and cancer.
households were allocated to PEP (n = 138 households with 410 HHCs) or expectant treatment (n = 139 …