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Postexposure prophylaxis with oseltamivir reduced influenza transmission in households

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 Q In household contacts (HHCs) (after index influenza [flu] patients received oseltamivir), is postexposure prophylaxis (PEP) more effective than oseltamivir treatment at the time of illness (expectant treatment) for preventing flu transmission?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Infectious diseases ★★★★★★☆


Embedded ImageDesign:

cluster (household level) randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:


Embedded ImageFollow up period:

30 days.

Embedded ImageSetting:

households in Europe and North America.

Embedded ImageParticipants:

812 HHCs (age range 1–83 y, 55% girls/women) of index patients with a flu like illness during a community flu outbreak. Eligible households had 3–8 members, including ⩾1 index patient and ⩾2 eligible contacts ⩾1 year of age. Exclusion criteria included pregnancy, breastfeeding, and cancer.

Embedded ImageIntervention:

households were allocated to PEP (n = 138 households with 410 HHCs) or expectant treatment (n = 139 …

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