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- cerebrovascular disorders
- cerebrovascular accident
- arterial occlusive diseases
- anticholesteremic agents
Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Neurology ★★★★★★☆ Geriatrics ★★★★★☆☆
METHODS
Design:
randomised controlled trial (Heart Protection Study).
Allocation:
{concealed*}†.
Blinding:
blinded {patients, clinicians, and data monitoring committee}†.*
Follow up period:
5 years.
Setting:
{69 hospitals in the UK}†.
Patients:
20 536 patients (mean age 64 y, 75% men) who had non-fasting total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary disease, other occlusive arterial disease, or diabetes, or were men ⩾65 years of age treated for hypertension. Exclusion criteria: clear indication …