Article Text

Download PDFPDF
Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Neurology ★★★★★★☆ Geriatrics ★★★★★☆☆


Embedded ImageDesign:

randomised controlled trial (Heart Protection Study).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, clinicians, and data monitoring committee}.*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

{69 hospitals in the UK}.

Embedded ImagePatients:

20 536 patients (mean age 64 y, 75% men) who had non-fasting total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary disease, other occlusive arterial disease, or diabetes, or were men ⩾65 years of age treated for hypertension. Exclusion criteria: clear indication …

View Full Text