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Valacyclovir reduced genital herpes transmission in couples discordant for herpes simplex virus type 2 infection
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 Q In heterosexual couples who are serologically discordant for herpes simplex virus type 2 (HSV-2) infection, does once daily valacyclovir reduce the sexual transmission of genital herpes?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Infectious diseases ★★★★★☆☆

METHODS

Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:

concealed.*

Embedded ImageBlinding:

blinded {participants, healthcare providers, data collectors, data analysts, and outcome assessors}.*

Embedded ImageFollow up period:

8 months.

Embedded ImageSetting:

96 sites in the US, Canada, Europe, Latin America, and Australia.

Embedded ImageParticipants:

1498 couples ⩾18 years who were immunocompetent, heterosexual, monogamous, in good health, and using effective contraception. One (source) partner had clinically symptomatic genital HSV-2 infection, presence of recurrent genital herpes with <10 episodes/year, and non-use of any daily antiviral therapy. The other (susceptible) partner had HSV-2 seronegativity on Western …

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