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Therapeutics
Review: artesunate added to standard drug treatment reduces treatment failure in malaria

https://doi.org/10.1136/ebm.9.5.150

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    International Artemisinin Study Group. Artesunate combinations for treatment of malaria: meta-analysis. Lancet 2004;363:9–17.
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 Q In patients with acute, uncomplicated Plasmodium falciparum malaria, does the addition of an artemisinin derivative (artesunate) to existing drug treatment reduce treatment failure and transmission potential?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Infectious disease ★★★★★☆☆ Tropical medicine ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Medline, Cochrane Central Register of Controlled Trials, and investigators in the field. Individual patient data were requested from the original trial datasets.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) comparing artesunate plus a standard antimalarial drug with a standard drug alone for acute, uncomplicated P falciparum malaria. Study quality was assessed by adequacy of random allocation, inclusion of …

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    Footnotes

    • For correspondence: Professor P Garner, Liverpool School of Tropical Medicine, Liverpool, UK. pgarnerliv.ac.uk

    • Sources of funding: World Health Organization and Department for International Development UK.