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Clinical prediction guide
The BODE index predicted death in chronic obstructive pulmonary disease

https://doi.org/10.1136/ebm.9.5.156

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    Celli BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004;350:1005–12.
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 Q In patients with chronic obstructive pulmonary disease (COPD), how well does an index comprising the risk factors that reflect the respiratory, perceptive, and systemic aspects of the disease predict outcome?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Respirology ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    2 cohort studies, 1 for development and 1 for validation.

    Embedded ImageSetting:

    clinics in the US, Venezuela, and Spain.

    Embedded ImagePatients:

    832 patients (mean age 66 y) who had COPD with a wide range of severity, were in clinically stable condition, and were receiving appropriate therapy. Exclusion criteria: probability of death within 3 years from a cause other than COPD, asthma, inability to take the lung function and 6 minute walk tests, myocardial infarction within the previous 4 months, unstable angina, or congestive heart failure. 207 patients were recruited from 1995 to 1997 and formed the development cohort; 625 patients were recruited from 1997 to 2003 …

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    Footnotes

    • For correspondence: Dr B R Celli, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA, USA. bcellicopdnet.org

    • Source of funding: no external funding.