THERAPEUTICS
Duhmke R, Cornblath D, Hollingshead J. Tramadol for neuropathic pain. Cochrane Database Syst Rev 2004;(2):CD003726.
Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★☆☆☆ Neurology ★★★★☆☆☆
Merten GJ, Burgess WP, Gray LV, et al. Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA 2004;291:2328–34.
Clinical impact ratings Internal medicine ★★★★★★★ Cardiology ★★★★★★☆ Nephrology ★★★★★★☆
Siebenhofer A, Plank J, Horvath K, et al. Angiotensin receptor blockers as anti-hypertensive treatment for patients with diabetes mellitus: meta-analysis of controlled double-blind randomized trials. Diabet Med 2004;21:18–25.
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★☆☆
Mufson L, Dorta KP, Wickramaratne P, et al. A randomized effectiveness trial of interpersonal psychotherapy for depressed adolescents. Arch Gen Psychiatry 2004;61:577–84.
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★☆☆☆ Psychiatry ★★★☆☆☆☆
Jureidini JN, Doecke CJ, Mansfield PR, et al. Efficacy and safety of antidepressants for children and adolescents. BMJ 2004;328:879–83.
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★★★☆ Paediatrics ★★★★★★☆ Psychiatry ★★★★★★☆
Christ-Crain M, Jaccard-Stolz D, Bingisser R et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 2004;363:600–7.
Clinical impact ratings Internal medicine ★★★★★★☆ Infectious disease ★★★★★☆☆ Respirology ★★★★☆☆☆
Gheorghiade M, Gattis WA, ÒConnor CM, et al. Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA 2004;291:1963–71.
Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★☆☆
Gale EA, Bingley PJ, Emmett CL, et al. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004;363:925–31.
Clinical impact ratings Endocrine ★★★★★★☆
Genovese MC, Cohen S, Moreland L, et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum 2004;50:1412–9.
Clinical impact ratings Rheumatology ★★★★★★☆
Hanifin JM, Cooper KD, Ho VC, et al. Guidelines of care for atopic dermatitis. J Am Acad Dermatol 2004;50:391–404.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Dermatology ★★★★★★☆
Madisch A, Holtmann G, Plein K, et al. Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial. Aliment Pharmacol Ther 2004;19:271–9.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Gastroenterology ★★★★★★☆
Chang JT, Morton SC, Rubenstein LZ, et al. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ 2004;328:680.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Geriatrics ★★★★★☆☆
Kranke P, Bennett M, Roeckl-Wiedmann I, et al. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev 2004;(2):CD004123.
Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★★☆ Surgery ★★★★★☆☆
Hurskainen R, Teperi J, Rissanen P, et al. Clinical outcomes and costs with the levonorgestrel-releasing intrauterine system or hysterectomy for treatment of menorrhagia: randomized trial 5-year follow-up. JAMA 2004;291:1456–63.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Gynaecology ★★★★★☆☆
Schroeder K, Fahey T, Ebrahim S. Interventions for improving adherence to treatment in patients with high blood pressure in ambulatory settings. Cochrane Database Syst Rev 2004;(2):CD004804.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆
Becker A, Watson W, Ferguson A, et al. The Canadian asthma primary prevention study: outcomes at 2 years of age. J Allergy Clin Immunol 2004;113:650–6.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Respirology ★★★★★☆☆ Paediatrics ★★★★★☆☆
Asano T, McLeod R. Non steroidal anti-inflammatory drugs (NSAID) and Aspirin for preventing colorectal adenomas and carcinomas. Cochrane Database Syst Rev 2004;(2):CD004079.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Gastroenterology ★★★★★☆☆ Oncology ★★★★☆☆☆
Siebenhofer A, Plank J, Berghold A, et al. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus. Cochrane Database Syst Rev 2004;(2):CD003287.
Clinical impact ratings GP/FP/Primary ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★☆☆
Del Mar C, Glasziou P, Spinks A. Antibiotics for sore throat. Cochrane Database Syst Rev 2004;(2):CD000023.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Emergency Medicine ★★★★★☆☆ Infectious disease ★★★★☆☆☆
Mittelman MS, Roth DL, Coon DW, et al. Sustained benefit of supportive intervention for depressive symptoms in caregivers of patients with Alzheimer’s disease. Am J Psychiatry 2004;161:850–6.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Mental health ★★★★★☆☆ Geriatrics ★★★★★☆☆
Klassen T, Belseck E, Wiebe N, et al. Acyclovir for treating varicella in otherwise healthy children and adolescents. Cochrane Database Syst Rev 2004;(2):CD002980.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Infectious disease ★★★★☆☆☆ Paediatrics ★★★★★☆☆
Stern L, Iqbal N, Seshadri P, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 2004;140:778–85.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★☆☆☆
Salpeter SR, Ormiston TM, Salpeter EE. Meta-analysis: respiratory tolerance to regular beta2-agonist use in patients with asthma. Ann Intern Med 2004;140:802–13.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Respirology ★★★★☆☆☆
Humphrey LL, Teutsch S, Johnson M. Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the U.S. Preventive Services Task Force. Ann Intern Med 2004;140:740–53.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Oncology ★★★★☆☆☆ Respirology ★★★★★☆☆
Fonseca BK, Holdgate A, Craig JC. Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med 2004;158:483–90.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Emergency Medicine ★★★★★☆☆ Paediatrics ★★★★★☆☆
Halterman JS, Szilagyi PG, Yoos HL, et al. Benefits of a school-based asthma treatment program in the absence of secondhand smoke exposure: results of a randomized clinical trial. Arch Pediatr Adolesc Med 2004;158:460–7.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Respirology ★★★★★★☆ Paediatrics ★★★★★☆☆
Paoloni JA, Appleyard RC, Nelson J, et al. Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial. J Bone Joint Surg Am 2004;86:916–22.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆
Steinberg JS, Sadaniantz A, Kron J, et al. Analysis of cause-specific mortality in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Circulation 2004;109:1973–80.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Cardiology ★★★★★☆☆ Neurology ★★★★☆☆☆
Sabatowski R, Galvez R, Cherry DA, et al. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Pain 2004;109:26–35.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Neurology ★★★☆☆☆☆
Goudswaard AN, Stolk RP, Zuithoff P, et al. Starting insulin in type 2 diabetes: Continue oral hypoglycemic agents? A randomized trial in primary care. J Fam Pract 2004;53:393–9.
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Endocrine ★★★★★☆☆
Wang CT, Lin J, Chang CJ, et al. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. J Bone Joint Surg Am 2004;86:538–45.
Clinical impact ratings GP/FP/Primary care ★★★★☆☆☆ Rheumatology ★★★★☆☆☆ Surgery ★★★☆☆☆☆
Kraemer WJ, Ratamess NA, Anderson JM, et al. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatol 2004;31:767–74.
Clinical impact ratings GP/FP/Primary care ★★★★☆☆☆ Rheumatology ★★★★★★☆
Allen S, Okoko B, Martinez E, et al. Probiotics for treating infectious diarrhoea. Cochrane Database Syst Rev 2004;(2):CD003048.
Clinical impact ratings GP/FP/Primary care ★★★☆☆☆☆ Gastroenterology ★★★★☆☆☆ Infectious disease ★★★★★☆☆
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