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Review: rotavirus vaccines moderately reduce rotavirus diarrhoea in children

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 Q In children and adults, are rotavirus vaccines effective for preventing rotavirus diarrhoea?

Clinical impact ratings Paediatrics ★★★★★★☆ Tropical medicine ★★★★★☆☆ Infectious disease ★★★★☆☆☆


Embedded ImageData sources:

Cochrane Infectious Diseases Group’s trials register, Medline, EMBASE/Excerpta Medica, LILACS, Biological Abstracts (all up to October 2003), Cochrane Central Register of Controlled Trials (2003, Issue 3), bibliographies of relevant articles, and contact with researchers and a rotavirus manufacturer (Merck Sharp & Dohme).

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) in any language that compared rotavirus vaccines with placebo, no vaccination, or a different rotavirus vaccine in children or adults. Study quality was assessed for method of allocation, allocation concealment, blinding, sample size, exclusions after randomisation, and follow up period.

Embedded ImageOutcomes:

rotavirus diarrhoea, all cause diarrhoea, all cause mortality, and adverse events.


63 RCTs of …

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  • For correspondence: Dr K Soares-Weiser, Bar Ilan University, Kfar-Saba, Israel.

  • Sources of funding: Nuffield Trust UK and Cochrane Child Health Field Bursary Scheme Canada.