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Q In children and adults, are rotavirus vaccines effective for preventing rotavirus diarrhoea?
Clinical impact ratings Paediatrics ★★★★★★☆ Tropical medicine ★★★★★☆☆ Infectious disease ★★★★☆☆☆
Cochrane Infectious Diseases Group’s trials register, Medline, EMBASE/Excerpta Medica, LILACS, Biological Abstracts (all up to October 2003), Cochrane Central Register of Controlled Trials (2003, Issue 3), bibliographies of relevant articles, and contact with researchers and a rotavirus manufacturer (Merck Sharp & Dohme).
Study selection and assessment:
randomised controlled trials (RCTs) in any language that compared rotavirus vaccines with placebo, no vaccination, or a different rotavirus vaccine in children or adults. Study quality was assessed for method of allocation, allocation concealment, blinding, sample size, exclusions after randomisation, and follow up period.
rotavirus diarrhoea, all cause diarrhoea, all cause mortality, and adverse events.
63 RCTs of …
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