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Q In patients with osteoarthritis (OA) of the knee or hip, are non-steroidal anti-inflammatory drugs (NSAIDs) more effective than paracetamol (acetaminophen) for reducing OA related pain or disability?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★☆☆☆☆☆
Medline, EMBASE/Excerpta Medica, and the Cochrane Database (all up to December 2001), and bibliographies of relevant articles.
Study selection and assessment:
randomised controlled trials (RCTs) (full reports published in any language) that compared an NSAID with paracetamol in patients with OA of the hip or knee, and measured relevant outcomes. Study quality was assessed using the internal validity criteria of the Amsterdam-Maastricht Consensus List for Quality Assessment with emphasis on adequate procedures for randomisation and sufficient blinding (maximum score 11 points).
overall change in pain and disability (physician assessment), pain on motion …
For correspondence: Dr D van der Windt, Institute for Research in Extramural Medicine, Amsterdam, The Netherlands.
Source of funding: Leo Pharma.