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  • Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children

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Therapeutics
Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children

https://doi.org/10.1136/ebm.9.6.181

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    Whittington CJ, Kendall T, Fonagy P, et al. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet 2004;363:1341–5.
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 Q Are selective serotonin reuptake inhibitors (SSRIs) safe and effective for treating depression in children?

    Clinical impact ratings Mental health ★★★★★★☆ Psychiatry ★★★★★★☆ Paediatrics ★★★★★★☆ GP/FP/Primary care ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Medline, CINAHL, EMBASE/Excerpta Medica, and PsycINFO (to April 2003); Cochrane Library; reference lists; tables of contents; previous systematic reviews; Guideline Development Group information; and written requests to experts.

    Embedded ImageStudy selection and assessment:

    English language randomised controlled trials (RCTs) or RCTs with English abstracts that compared SSRIs with placebo in children (5–18 y) with depression; had adequate blinding, concealed allocation, and a description of withdrawals; and were published in peer reviewed …

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    Footnotes

    • For correspondence: Dr C Whittington, University College London, London, UK. c.whittingtonucl.ac.uk

    • Source of funding: no external funding.