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Q In patients with high risk malignant melanoma, is primary tumour excision with a surrounding margin of 3 cm more effective than a margin of 1 cm for reducing recurrence and improving survival?
Clinical impact ratings Dermatology ★★★★★★☆ Oncology ★★★★★★☆ Surgery ★★★★☆☆☆
randomised controlled trial.
blinded (monitoring committee).*
Follow up period:
a median of 60 months.
21 hospitals, 2 infirmaries, 1 cancer therapy network in the UK, and 1 cancer centre in Poland.
900 patients >18 years of age (mean age 57 y, 52% men) who had a single primary localised cutaneous melanoma (⩾2 mm in thickness) on the trunk or limbs (excluding the palms of hands or the soles of the feet) where a 3 cm excision margin was technically possible. Exclusion criteria included pregnancy, a history of cancer (except basal cell carcinoma), and treatment with immunosuppressive agents.
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