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Review: negative ELISA results are best for excluding a diagnosis of deep venous thrombosis or pulmonary embolism

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 Q What are the test characteristics of various d-dimer assays for diagnosis of deep venous thrombosis (DVT) or pulmonary embolism (PE)?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Haematology ★★★★★☆☆ Respirology ★★★★★☆☆


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PubMed (1983 to January 2003), EMBASE/Excerpta Medica (1988 to January 2003), and bibliographies of retrieved articles.

Embedded ImageStudy selection and assessment:

published prospective trials in any language that included a specific statement that DVT or PE was being diagnosed, used objective tests for diagnosis, included a broad spectrum of consecutive patients with suspected DVT or PE, included patients with and without disease, independently interpreted d-dimer and diagnostic standard results, made the decision to perform the diagnostic standard independent of d-dimer …

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  • For correspondence: Dr P D Stein, Saint Joseph Mercy-Oakland, Pontiac, MI, USA.

  • Source of funding: not stated.