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Q Does the risk of recurrent venous thromboembolism (VTE) differ between men and women?
Clinical impact rating GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Haematology ★★★★★★☆
METHODS
Design:
inception cohort followed for a median of 26 months (Austrian Study on Recurrent Venous Thromboembolism).
Setting:
4 thrombosis centres in Vienna.
Patients:
826 patients >18 years of age (mean age 48 y, 55% women) who had a first episode of VTE and had been treated with oral anticoagulants for ⩾3 months. Patients had received standard heparin at doses designed to keep the activated partial thromboplastin time 1.5–2.0 times that of the control value or had received subcutaneous low molecular weight heparin at therapeutic doses. Exclusion criteria: surgery, trauma, or pregnancy in the previous 3 months; known deficiency of antithrombin, protein C, or protein S; lupus anticoagulant; cancer; or need for long term treatment …