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Randomised controlled trial
Catheter-based renal sympathetic denervation reduces systolic blood pressure by 32 mm Hg in people with treatment-resistant hypertension
  1. Richard E Katholi1,
  2. Krishna J Rocha-Singh1
  1. 1Prairie Cardiovascular Consultants, Springfield, Illinois, USA
  1. Correspondence to: Richard E Katholi
    Prairie Cardiovascular Consultants, PO Box 19420, Springfield, IL 62794-9420, USA; rkatholi{at}

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The kidney plays an essential role in the regulation of blood pressure through sodium, volume, renin modulation and renal-sympathetic neuronal interactions. Over many years, the contribution of the renal nerves has been investigated by renal denervation in experimental animal models and by mainly indirect techniques in humans.1 2 Depending on the setting, the contribution to hypertension may be mediated mainly by activation of the efferent or afferent sympathetic renal nerves which lie within and immediately adjacent to the wall of the renal arteries. As the causative factors of hypertension change over time, denervation of efferent and afferent nerves should result in long-term attenuation of hypertension. The importance of the renal nerves in patients with resistant essential hypertension can now be defined …

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