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Cohort study
High-potency statins are associated with increased hospitalisations with acute kidney injury
  1. Daniel O Keys,
  2. Charles L Edelstein
  1. University of Colorado Denver, Aurora, Colorado, USA
  1. Correspondence to: Professor Charles L Edelstein
    University of Colorado Denver, 12700 East 19th Avenue, Renal Box C 281, Aurora, CO 80045, USA; charles.edelstein{at}

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Commentary on: Dormuth CR, Hemmelgarn BR, Paterson JM, et al. Canadian Network for Observational Drug Effect Studies (CNODES). Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases. BMJ 2013;346:f880.


Statins are commonly used medications for the reduction of low-density lipoprotein cholesterol resulting in markedly improved cardiovascular disease outcomes.1 Prior studies with regard to acute kidney injury (AKI) risk in statin users versus non-statin users show mixed results. Dormuth and colleagues address the question of whether high-potency statin therapy is associated with increased hospitalisation for AKI compared to low-potency statin therapy, thereby decreasing indication bias for statin use as a confounder.


The Canadian Network for Observational Drug Effect Studies (CNODES) are an observational retrospective database meta-analysis of 2 008 003 patients without chronic kidney disease (CKD) and 59 636 with CKD. Patients …

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