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Increased incidence of postpartum haemorrhage (PPH) is reported in a number of high-resource settings since the 1990s. The increase appears unrelated to factors such as rising rates of caesarean sections or increasing maternal age.1 Recent studies have investigated the association between antidepressant use at different stages of pregnancy and PPH, with two studies demonstrating a 1.20-fold2 and 1.45-fold3 increased risk of bleeding at delivery, while another reported no association.4 Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed and may impair platelet function by blocking serotonin uptake into platelets and impairing their homeostatic ability. Palmsten and colleagues aimed to assess the association between exposure to antidepressants—particularly SSRIs—at the time of delivery, …
Competing interests None.