Statin drugs have become the mainstay of many cardiovascular disease prevention guidelines and are recommended for most adult patients with diabetes. A careful review of the evidence, however, suggests that the clinical benefits of statins in diabetes may have been overstated by relying on meta-analyses that incorporate randomised controlled trials (RCTs) neither designed nor powered to assess the effects of statins in diabetes. Multiple RCTs specifically designed and powered to study the effects of statins in diabetes have demonstrated inconsistent clinical benefits and no mortality benefit. The conclusions of these meta-analyses should not supersede the results of these large, well-conducted RCTs. Reports that conclude that the benefits of statins outweigh the risks have probably underestimated the long-term risks of statin exposure and the deleterious consequences of long-term diabetes.
- PREVENTIVE MEDICINE
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.