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Systematic review with meta analysis
The risk of arterial thrombosis increases with the use of combined oral contraceptives
  1. Øjvind Lidegaard
  1. Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  1. Correspondence to: Dr Øjvind Lidegaard, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, DK-2100, Denmark; Oejvind.Lidegaard{at}

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While the risk of venous thrombosis with use of combined oral contraceptives (COC) is now convincingly quantified to be threefold to sixfold increased, depending mainly on the type of progestogen, there are few and less consistent studies on the risk of arterial endpoints. Therefore, a meta-analysis on available evidence might be relevant.


This Cochrane review includes data from 24 studies assessing the risk of thrombotic stroke and/or myocardial infarction in women of reproductive age using COC as compared with non-users. Criteria for including and excluding studies were specified, as was information on categorising the studies’ …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.