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Systematic review
Ibuprofen for the treatment of TTH
  1. Roy G Beran
  1. University of NSW, Liverpool Hospital, Elizabeth Drive, Liverpool 2170; Griffith University, Gold Coast, Queensland; and Strategic Health Evaluators, Sydney, NSW, Australia
  1. Correspondence to: Professor Roy Beran, South Western Sydney Clinical School, Goulburn St, Liverpool NSW 2170, Australia; roy.beran{at}

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Tension-type headache (TTH) is the most common form of primary headache. Aetiology of TTH is far from categorical, as is reflected by the wealth of synonymous identifiers, such as tension headache, muscle contraction headache, psychomyelogenic headache or psychogenic headache, to name but a few. The condition can however be divided into infrequent, more frequent and chronic forms, based on the number of headaches and headache days per month. Infrequent episodic TTH has a prevalence rate of approximately 40% while almost one-third of 40-year-olds have frequent episodic TTH, having a profound negative impact on societal productivity.1

Most of those who experience episodic TTH self-medicate with over-the-counter (OTC) remedies of which ibuprofen is but one available treatment.


The purpose of the study was to evaluate the efficacy of …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.