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Systematic review with meta analysis
Treatment for chronic Strongyloides stercoralis infection: moderate-to-low evidence shows that ivermectin is more effective and tolerable than albendazole and thiabendazole, respectively
  1. Dora Buonfrate,
  2. Federico Gobbi
  1. Centre for Tropical Diseases, Ospedale Sacro Cuore Don Calabria, Negrar, Italy
  1. Correspondence to : Dr Federico Gobbi, Centre for Tropical Diseases, Ospedale Sacro Cuore Don Calabria, Via Sempreboni 5, Negrar 37024, Italy; federico.gobbi{at}

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Hundreds of millions of people around the world are estimated to be infected by Strongyloides stercoralis.1 Strongyloidiasis is a soil-transmitted helminthiasis that can persist indefinitely in the infected host if not adequately treated, because of a peculiar autoinfective cycle. Chronic infection is characterised by non-specific symptoms of variable intensity (asymptomatic infection can also occur), mainly relating to the gastrointestinal tract. However, strongyloidiasis is particularly relevant because it can cause a severe syndrome in immunocompromised patients (hyperinfection/dissemination), associated with high mortality.2 Therefore, all infected patients, irrespective of presence of symptoms, should receive a treatment that can guarantee a cure, in order to …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.