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Randomised controlled trial
Caloric restriction improves health-related quality of life in healthy normal weight and overweight individuals
  1. W Scott Butsch1,
  2. Fatima Stanford2
    1. 1Harvard Medical School, Boston, Massachusetts, USA
    2. 2Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA
    1. Correspondence to : Dr W Scott Butsch, Harvard Medical School, Massachusetts General Hospital Weight Center, Boston, MA 02114, USA; wbutsch{at}

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    Studies have demonstrated that caloric restriction (CR) increases longevity in animals and also decreases the risk of diabetes, cardiovascular disease and cancer in humans without obesity.1 ,2 It is hypothesised that these favourable CR effects may be related to a reduction in metabolism, reduced core temperature and lowered triiodothyronine(T3).3 While it is unlikely that studies will ascertain whether CR extends life, intermediate length studies may be able to determine the safety, tolerability and feasibility of CR and its effects on chronic disease development and biomarkers correlated with longevity.2 This study aimed to examine the sustained effects of a 25% CR on health-related quality of life (QOL) in individuals without …

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