Article Text

other Versions

PDF
Therapeutics
Study supports augmentation with a non-antidepressant agent over combining or switching antidepressants in unipolar depression
  1. Stephan Köhler,
  2. Philipp Sterzer
  1. Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany
  1. Correspondence to PD Dr. Stephan Köhler, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin 10117, Germany; stephan.koehler{at}charite.de

Statistics from Altmetric.com

Commentary on: Mohamed S, Johnson GR, Chen P, et al. Effect of antidepressant switching vs augmentation on remission among patients with major depressive disorder unresponsive to antidepressant treatment: the VAST-D randomized clinical trial. JAMA 2017;318,132–45.

Context

Fifty per cent of patients with a major depressive disorder (MDD) do not yield a satisfactory response to an antidepressant. Even after several treatment approaches, the rate of patients with refractory depression is still 30%.1 In case of non-response to therapy, adding a drug from a different pharmaceutical class to the antidepressant treatment has been shown to have an augmentative effect.2 Most evidence is available for augmentation with lithium3 and atypical antipsychotics.4 Evidence for switching to another antidepressant is far weaker.5 The efficacy of combining two antidepressants is limited to some specific combinations.6 The Veterans Affairs Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) randomised controlled trial (RCT) …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.