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General Medicine
Edoxaban is non-inferior to low-molecular-weight heparin for treating cancer-associated venous thromboembolism
  1. Lori-Ann Linkins MD, MSc, FRCPC
  1. Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Juravinski Hospital, Room A3-74, Hamilton, Ontario, Canada
  1. Correspondence to Dr Lori-Ann Linkins MD, MSc and FRCPC, Hematology, McMaster University Department of Medicine, Hamilton, Ontario L8S 4K1, Canada; linkinla{at}

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Commentary on: Raskob GE, van Es N, Verhamme P, et al. Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med. 2018 Feb 15;378:615–624.


Low-molecular-weight heparin (LMWH) is the standard of care for treatment of cancer-associated venous thromboembolism (VTE).1 2 This recommendation is supported largely by a landmark randomised controlled trial (RCT) that showed that patients with cancer who received 6 months of dalteparin instead of warfarin (after an initial 5–7 days of dalteparin) had a 52% risk reduction for recurrent VTE.3 However, LMWH injections can be painful as well as anxiety provoking. A pill would be a welcome alternative for most patients, but only if it is as …

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  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.