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General medicine
Drug discovery today: no molecules required
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  • Published on:
    Defamation: no evidence required
    • Sergey Tarasov, Director of Research & Development Department OOO “NPF “Materia Medica Holding”

    The article “Drug discovery today: no molecules required” (2018) (by Panchin AY, Khromov-Borisov NN, Dueva EV) questions the imperfections in reviewing scientific publications. The authors use the example of publications on released-active drugs (RA-drugs) as a basis for the paper and their accusations against journal editorial boards. The authors postulate that these drugs do not contain any active ingredients due to the technology used and therefore come to the conclusion that the reviewers and journal editors who have published articles on RA-drugs carried out their work appallingly and made gross mistakes. So the authors state «…the vast amount of flawed publication claiming therapeutic properties and physiological effects of drugs with no active components can highlight the problems of peer-review standards and policies in biomedical journals».
    This particular conclusion is based on approximate theoretical calculations and not on experimental evidence: «If one assumes a 1M initial antibodies concentration (though this is usually not disclosed in release-activity papers) and takes into account Avogadro’s constant (~6.02×10^23 mol^(−1)), then even C12 dilutions are unlikely to contain any antibody molecules». In their article, the authors present these calculations as the main argument to complain to journals. It is noteworthy that in the article the authors do not provide any data or references to any studies conducted by themselves. Neither do the authors provid...

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    Conflict of Interest:
    Tarasov SA is employee of OOO “NPF “Materia Medica Holding”, the company, which produces and markets RA-drugs. Tarasov SA is co-author in the papers dedicated to the RA-drugs described in the article by Panchin et al. (2018) BMJ Evidence-Based Medicine. doi: 10.1136/bmjebm-2018-111121. Tarasov SA is co-author of several patents dedicated to RA-drugs. OOO “NPF “Materia Medica Holding” has sued Khromov-Borisov NN (А40-148616/2018) (http://kad.arbitr.ru/Card/a74a5f06-fff8-4b4a-b5c0-3f97c33d36c1; in Russian).